OsteoDenx®

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OsteoDenx®, a patented US innovation, represents a significant advancement in bone and joint health supplements. Its unique Syno-PORTIN® Complex, enriched with milk-derived R-ELF, specifically targets the synovium for precise nutrient delivery. This scientifically-proven formula has been shown to enhance bone mineral density, support joint cartilage integrity, and maintain optimal nutrient balance for a healthy skeletal system. It outperforms traditional vitamin and mineral supplements in terms of absorption and integration.

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Transformed Lives, True Stories

 

 

" Hi, I'm John. About a year ago, I was in a severe motorcycle accident and underwent five surgeries. Recovery seemed uncertain until I found OsteoDenx®. After extensive research, I started taking it in high doses. Within six months, I was not only walking but also returning to hiking, swimming, and surfing. OsteoDenx® dramatically improved my mobility and confidence. It’s a crucial part of my health regimen now, and I recommend it wholeheartedly."

 

John St Clair

 

 

 

 

" As a Tai Chi instructor, I understand the importance of inner strength. Discovering Dr. Narain Naidu's products in 2009 transformed my approach to bone health. OsteoDenx® have not only reduced bone loss but also improved my overall vitality—stronger nails, thicker hair, and better bone density. I confidently recommend them to my students for a healthier, more balanced life."

 

Elliotte Mao

 

 

 

 

" Hello there! My name is Connie D'Amico. I’ve been using OsteoDenx® since its inception. At 84, I'm a testament to its effectiveness. Just look at my posture! My bones are strong, and I remain flexible, allowing me to attend creative dance classes four times a week. And yes, I still strut around in my high heels. I absolutely love OsteoDenx® and the vitality it brings to my golden years."

 

Connie D'Amico

 

 

 

 

" My name is Linda Morris. bioQuad’s Bioreplenishment products have transformed my family's health. After my 87-year-old mother started using OsteoDenx® and Lactoferrin Gold 1.8®, her mobility improved dramatically. Just six months later, she was moving comfortably again, with significantly less discomfort in her hips and knees. These products are more than supplements; they're a crucial part of our wellness routine. Thanks to bioQuad, my mother is thriving."

 

Linda Morris

 

Bio-Replenishment® for

Bio-Replenishment® for Bone and Joint Health

Bone and Joint Health

OsteoDenx®, a patented formula for bone and joint health, showcases the innovative Syno-Portin® Complex designed for targeted nutrient delivery. This unique system, based on ribonuclease-enriched lactoferrin (R-ELF), combines bioactive proteins lactoferrin and ribonuclease, offering multifaceted health benefits through a distinct mechanism of action.

OsteoDenx®, a patented formula for bone and joint health, showcases the innovative Syno-Portin® Complex designed for targeted nutrient delivery. This unique system, based on ribonuclease-enriched lactoferrin (R-ELF), combines bioactive proteins lactoferrin and ribonuclease, offering multifaceted health benefits through a distinct mechanism of action.

In a rigorous clinical trial approved by the Institutional Review Board (IRB), R-ELF, a key component of synovial fluid that influences bone turnover, was compared against a calcium/vitamin D placebo. Published in reputable medical journals, the results demonstrated that R-ELF significantly enhanced osteoblastic activity, optimized bone resorption, and improved joint comfort within six months, surpassing the placebo group.

In a rigorous, IRB-approved clinical trial, R-ELF, a key component of synovial fluid influencing bone turnover, was tested against a calcium/vitamin D placebo. Results, published in leading medical journals, showed that R-ELF significantly enhanced osteoblastic activity, optimized bone resorption, and improved joint comfort within six months, outperforming the placebo group.

Bioactive Matrix

Lactoferrin-(TCR)

Enhances absorption &
delivery of nutrients 

Collagen

Boosts flexibility &
supports joint function

Vitamin K2

Promotes blood flow &
bone remodeling 

Vitamin D3

Improves calcium uptake &
strengthens bones

Boswellia

Eases joint pain & protects cartilage

Lactoferrin-(TCR)

Enhances absorption &
delivery of nutrients 

Collagen

Boosts flexibility &
supports joint function

Vitamin K2

Promotes blood flow &
bone remodeling 

Vitamin D3

Improves calcium uptake &
strengthens bones

Boswellia

Eases joint pain & protects cartilage

OsteoDenx® represents a groundbreaking supplement designed to effectively support both bones and joints. Powered by the patented Syno-Portin Complex® with ribonuclease-enriched lactoferrin, it has been clinically proven to fortify the entire skeletal system. Additionally, it is fortified with a balanced blend of collagen, boswellia, resveratrol, vitamins, and minerals.

This dual-action formula makes OsteoDenx® an outstanding choice for promoting bone and joint health, showcasing the full potential of a two-in-one formula.

All Natural

Non-GMO

Lactose-Free

Gluten-Free

Soy-Free

No Preservatives

Amount per Serving
% DV
Copper (as sulfate)
0.5 mg
55
Vitamin D3 (as Cholecalciferol)
10 µg
50
Manganese (as sulfate)
1 mg
43
Selenium (as Selenomethionine)
22 µg
40
Vitamin K2 (as Menaquinone, MK7)
37.5 µg
31
Folate (as Folic acid)
100 µg.DFE
25
Syno- PORTIN® Complex
RNase-enriched lactofrrin (R-ELF) +
Collagen peptides (from fish) +
Boswellia (from Boswellia serrata)
350 mg
Trans-Resveratrol
10 mg

Other Ingredients:

Vegetable capsules, Rice flour, Calcium carbonate, Magnesium stearate, Silicon dioxide, Citric acid & Sodium bicarbonate.

⊹ Daily Value not established

Why OsteoDenx®?

What is OsteoDenx®?

OsteoDenx® is a pioneering bone and joint health technology with a unique mechanism of action that provides numerous health benefits. This advanced formula has been granted protection by four US patents. OsteoDenx® features the Syno-Portin® Complex, a novel targeted nutrient delivery system based on ribonuclease-enriched lactoferrin (R-ELF). R-ELF is a precisely calibrated mixture of two multifunctional bioactive proteins sourced from milk, specifically lactoferrin and ribonuclease (also known as angiogenin or RNAse types 2 and 4).

R-ELF is a crucial component of synovial fluid that plays a significant role in bone turnover. The bone and joint health benefits of R-ELF (Active group) were evaluated and compared to calcium/vitamin D supplementation (placebo group). In an Institutional Review Board (IRB)-approved, randomized, double-blind, placebo-controlled human clinical study, participants administered R-ELF demonstrated a statistically significant increase in osteoblastic activity, optimized bone resorption, and reported improvement in joint comfort within six months compared to the placebo group. The study results were published in top-tier, peer-reviewed medical journals.

How does it work?

Bone Strength - OsteoDenx® is a groundbreaking supplement clinically proven to enhance bone strength and density. This innovative formula, powered by the patented SynoPortin® Complex, promotes bone formation by stimulating osteoblasts and minimizes bone loss by regulating osteoclast activity, ensuring balanced bone remodeling essential for maintaining skeletal integrity. Besides its cellular benefits, OsteoDenx® effectively improves the body’s absorption and utilization of vital bone nutrients, particularly calcium. This combination of cellular support and nutrient optimization positions OsteoDenx® as a comprehensive solution for sustaining and enhancing bone health, providing a solid foundation for overall skeletal wellness.

Joint Relief - OsteoDenx® is a potent supplement for joint support, scientifically formulated to bolster chondrocytes, the cells crucial for maintaining cartilage health. The unique formula is highly effective in mitigating inflammation, a major contributor to joint discomfort and stiffness, thereby improving joint comfort and increasing flexibility. Beyond immediate relief, OsteoDenx® plays a critical role in safeguarding cartilage structure, fostering enduring healthy joint function. Its advanced ability to neutralize free radicals provides sustained protection against oxidative stress, promoting long-term, pain-free mobility and peak joint performance.

Why do you need it?

The importance of a healthy skeletal system spans across age, gender, diet, and lifestyle. It is essential for individuals to take proactive measures to ensure skeletal health, including maintaining an active lifestyle and a balanced diet.

  • Active Lifestyle - The strength of bones and joints relies on the principle of 'use it or lose it'. Sedentary lifestyles or obesity can lead to a weakened skeletal system, while excessive use can result in 'wear and tear'. Regular, moderate weight-bearing exercise is recommended to prevent such issues.
  • Balanced Diet - Diet provides the energy and nutrients needed to maintain skeletal structure and function. The body converts dietary nutrients into its own regulatory molecules, known as bio-replenishments. Factors like poor diet, stress, and aging can lead to a decline in bio-replenishment synthesis. Supplementing the body with bio-replenishments, such as Lactoferrin and ribonucleases, can support overall wellness.

Incorporating OsteoDenx® into a daily nutritional regimen is a proactive approach to maintaining healthy bones and joints, especially when maintaining an active lifestyle and balanced diet is challenging.

Recommended Use

Take 1 (ONE) capsule orally per day, with or without food, preferably at bedtime. Double the recommended dosage during the first month of use. Depending on lifestyle, age, and health status, the dosage can be increased to two or three capsules orally per day.

Study I: Provide Joint Relief

Bones and joints collaborate to facilitate movement, operating akin to a joist and lever system. To function optimally, joints must maintain structure, sustain lubrication (like synovial fluid), and clear debris (a natural byproduct of wear-and-tear). The immune system plays a crucial role in joint protection, constantly monitoring their condition. Excessive wear-and-tear prompts the immune system to release various cytokines, signaling a 'high alert' state. Achieving optimal joint health necessitates addressing and maintaining the balance of these processes.

A six-month, randomized clinical study was conducted on 35 healthy, post-menopausal women, aged 45 to 60 years. They were randomized into placebo or R-ELF supplement group; the R-ELF group was supplemented with R-ELF (2x 125 mg/day) and calcium (100% RDA), while the placebo group received only the calcium supplement. Serum levels of receptor activator for NF-κB ligand (RANKL), C-reactive protein (CRP) and various other cytokines were determined by ELISA. IL-6 and TNF-α decreased significantly (-44% and -10% respectively) while IL-10 increased (140%) with R-ELF supplementation. RANKL and CRP were modestly reduced (-50%) relative to the placebo, while RANKL elevated initially. R-ELF supplementation showed beneficial effects on joint health.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2010) Milk ribonuclease-enriched lactoferrin supplementation in women. J Infl Res 59(11):971-978..
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Study II: Improve Bone Density

The bone is a dynamic tissue that undergoes continuous remodeling through cycles of breakdown and regeneration. In healthy adults, the rate of new bone formation roughly equals that of bone resorption. However, with age and due to factors such as diet, lifestyle, and medications, this balance can shift towards increased bone resorption. Reduced angiogenesis may also contribute to this imbalance. Maintaining healthy bone turnover is crucial for reinforcing skeletal structure and optimizing its function.
A total of 35 healthy, post-menopausal women, aged 45 to 60 years, were randomized into placebo or R-ELF supplement group. Over a six-month period, the bone status was monitored by assessing bone resorption markers, serum N-telopeptides (sNTx) and urine deoxypyridinoline (uDpd) cross-links; and serum bone formation markers, bone-specific alkaline phosphatase (SBAP) and osteocalcin (sOC). R-ELF supplmentation demonstrated a decrease in uDpD levels by 14% (19% increase in placebo) and sNTx maintained at 25% of the baseline (41% for placebo), while serum BAP and OC levels showed a 45% and 16% elevation (25% and 5% for placebo). R-ELF supplementation showed positive effects on healthy bone turnover.
Reference: Bharadwaj S, Tezus Naidu AG, Betagiri GV, Prasadarao NV, Naidu AS (2009) Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers. Osteo Int 20(9):1603-1611.
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Not all Bone and Joint Supplements are Equal

Promotes Bone Growth
Maintains Bone Density
Improves Joint Mobility
Supports Mineral Balance
Optimizes Nutrient Absorption
Easy One Capsule / Day Dose
Patented Technology
Clinically-Proven Formula
All Natural Ingredients
Ideal for All Ages (Depends)
Dose

Your Questions - Answered

What are Bio-Replenishments?

Bio-replenishments are bio-active molecules that are produced and expended by the body on a regular basis. Examples include insulin, hormones, lactoferrin and ribonuclease. These molecules regulate our metabolism and maintain physiological balance or ‘homeostasis’. Any deficiency or dysfunction of bio-replenishments manifests as disorder(s), disease(s) or death.

What is OsteoDenx®?

OsteoDenx® is a patented, clinically-proven, dual-action supplement designed to enhance both bone and joint health. It strengthens the skeletal system, improves bone density, and regulates bone remodeling process. Additionally, OsteoDenx® promotes the absorption and utilization of vital bone nutrients, particularly calcium, ensuring optimal skeletal wellness. This comprehensive support makes OsteoDenx® an essential foundation for overall skeletal health.

What is R-ELF?

Ribonuclease-Enriched Lactoferrin (R-ELF) or Lactoferrin and ribonuclease are proteins naturally produced inside the body. They co-exist in milk and other biological fluids as key regulatory molecules with specific role in various physiological pathways. From a skeletal system perspective, the proteins combined help promote healthy bone turnover and maintain healthy joints.

What are the health benefits of taking OsteoDenx®?

Regular intake of OsteoDenx® helps in the formation of healthy bone tissue, supporting healthy bone density, protecting and lubricating joints, and enhancing the absorption of essential nutrients.

Who can benefit from OsteoDenx®?

OsteoDenx® is crafted for individuals of all ages, irrespective of their dietary habits or daily routines. It is particularly advantageous for those who face challenges such as joint discomfort, limited mobility, weak bones, or poor nutrient absorption. OsteoDenx® provides targeted support for optimal bone and joint health, making it a valuable addition to your daily regimen to maintain a robust skeletal system.

What makes OsteoDenx® unique?

The technology in OsteoDenx® is backed by over forty years of scientific research, two human clinical studies with published results and four US patents. OsteoDenx® is distinct from other generic vitamins or supplements because it helps support the body’s own process of building new bone tissue and lubricating joints for optimal mobility. In complementing this natural bone remodeling and repair process, OsteoDenx® can help promote strong, healthy bones and joints throughout life.

How is OsteoDenx® made?

OsteoDenx® is manufactured in Europe in a government certified manufacturing facility that meets current good manufacturing practices (cGMP) standards. Only the highest quality ingredients are sourced and third-party tested for purity. All ingredients also undergo meticulous testing at each stage of the production process, resulting in the safest, highest quality product.

Can individuals with lactose-intolerance take OsteoDenx®?

Yes. There is NO lactose sugar in OsteoDenx®.

Can individuals with milk protein allergy take OsteoDenx®?

Yes. Milk proteins that are reportedly associated with allergic reactions are: casein, casein derivatives (sodium and/or calcium-based), lactalbumin, beta-lactoglobulin and bovine serum albumin. R-ELF does not belong to this group of milk allergens. To our knowledge - any R-ELF associated or R-ELF mediated milk protein allergic reactions in human subjects has not been reported. However, if the person has any medical condition (including any milk protein allergy), it is advisable to consult with that person’s health care provider before use of this or any supplement.

Can individuals with gluten and/or soy intolerance take OsteoDenx®?

Yes. There is NO gluten or soy in OsteoDenx®.

Can pregnant women take OsteoDenx®?

Yes, a pregnant woman may take OsteoDenx®. However, those with any medical condition, including pregnancy, should consult a healthcare provider before using any supplements. 

Can children take OsteoDenx®?

Yes, a child above the age of 4 may take OsteoDenx®. However, it is advisable to consult with the child’s health care provider before use of this or any supplement.

What is the suggested dosage for OsteoDenx®?

The recommended dosage for OsteoDenx® is to take two capsules daily for the first month. After the first month, the dosage can be reduced to one capsule per day. However, some individuals, such as athletes, the elderly, and post-menopausal women, may benefit from continuing to take two capsules per day.

Should OsteoDenx® be taken with food or on an empty stomach; daytime or bedtime?

It is recommended to take OsteoDenx® at bedtime with or without food (because the mineral metabolism is most active during sleep).

Can OsteoDenx® be taken with other dietary supplements and medications?

Yes, you can take OsteoDenx® with other dietary supplements. However, if you have any medical conditions or are on medication, it's best to consult your healthcare provider before use.

Should OsteoDenx® not be taken with certain types of medications?

If a person has any medical condition (under any medication), it is advisable to consult with that person’s health care provider before use of this or any supplement.

Can OsteoDenx® be taken together with alcoholic beverages?

No. However, OsteoDenx® can be spaced at least 12 hours before or after consumption of an alcoholic beverage.

Can OsteoDenx® be taken together with hot beverages or foods?

No. However, OsteoDenx® is relatively stable at high temperatures and it is OK to consume this protein supplement with warm foods.

What are the side effects from taking OsteoDenx®?

No side effects have been reported with OsteoDenx®. However, if any discomfort is noticed by consuming OsteoDenx® immediately stop taking the product and consult your primary health care provider.